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#physiology

1 post1 participant0 posts today
Public
Charlie McHenry

Brain scans of infants reveal the moment we start making memories - A team from Columbia and Yale University scanned the brains of 26 infants and toddlers aged 4 to 25 months as they completed a memory task. They found that at roughly a year old, a part of the brain crucial to memory formation spun into action and began generating neural signals related to things the kids remembered from the tests. #memory #brain #physiology #BrainDevelopment #thinking #ChildGrowthAndDevelopment #consciousness
singularityhub.com/2025/03/20/

SingularityHub · Brain Scans of Infants Reveal the Moment We Start Making MemoriesA new study on "infantile amnesia" aims to answer a century-old mystery: Why can’t most us remember our earliest years?
Public
💧🌏 Greg Cocks

Scaling In Branch Thickness And The Fractal Aesthetic Of Trees [In Art From Da Vinci To Mondrian]
--
academic.oup.com/pnasnexus/art <-- shared paper
--
[not my usual fare, but love the spatial mathematical components, although the maths is way over my head!]
#spatial #maths #mathematics #art #painting #representation #daVinci #LeonardodaVinci #MurraysLaw #tree #vegetation #fractal #fractals #α #biology #artwork #radiusscalingexponent #branches #branching #nature #naturalpatterns #proportions #physiology #Mondrian #aesthetic #aesthetics #scale #scaling

a) da Vinci’s sketch of a tree illustrates the principle that combined thickness is preserved at different stages of ramification. b) Transects A and B have the same combined thickness and so limbs a and b together must have the same thickness as c. This has been taken to imply that c) combined cross-sectional area (⁠πR²⁠) is preserved across branching. Likewise, d) such transects can count the number of branches n that have radius approximately r to derive a fractal scaling relationship. Source: (a) from Institut de France Manuscript M, p. 78v.
sketch from one of Leonardo da Vinci's notebooks illustrating his original rules of trees
The scaling exponent α (a) determines the amount of detail at a given resolution and (b) proportions among adjoining boughs.
Trees in artwork across centuries, cultures, and styles exhibit fractal scaling. a) carved stone window screen of Sidi Saiyyed Mosque, Ahmedabad, Gujarat, India (1573 CE). b) Cherry Blossoms, Matsumura Goshun (1752–1811), ink on paper. c) L’Arbre de Vie (Tree of life), Gustav Klimt (1909), oil on canvas. d) data and inference of α±95% CI in two replicate measurements for each work along with simulated and living trees. Dotted vertical lines indicate the cutoff for excluding small-scale effects. Diameters from simulated and living trees are divided by this minimum value and therefore the horizontal axis is unitless.
Public
LabPlot

#LabPlot at the service of #science and #researchers!

@labplot@lemmy.kde.social

Boosts appreciated! :boost_love:🚀

We're pleased to know that #LabPlot was used in this recent study on ceftazidime-avibactam (CZA) tolerance/persistence:

▶️ link.springer.com/article/10.1

SpringerLinkCeftazidime-avibactam tolerance and persistence among difficult-to-treat KPC-producing Klebsiella pneumoniae clinical isolates from bloodstream infections - European Journal of Clinical Microbiology & Infectious DiseasesPurpose Tolerance and persistence occur “silently” in bacteria categorized as susceptible by antimicrobial susceptibility testing in clinical microbiology laboratories. They are different from resistance phenomena, not well-studied, and often remain unnoticeable. We aimed to investigate and characterize ceftazidime-avibactam (CZA) tolerance/persistence in 80 Klebsiella pneumoniae isolates from bloodstream infections. Methods We used the Tolerance Disk Test (TDtest) to detect CZA tolerance/persistence and investigate the avibactam (AVI) influence on them, and time-kill assays with minimal duration for killing (MDK) determination to characterize/differentiate CZA tolerance from persistence, for selected isolates. Whole genome sequencing was performed for 49/80 selected isolates to investigate genes related to beta-lactam tolerance/persistence and resistance as well as phylogeny studies. Results Tolerance/persistence to CZA was detected in 48/80 (60%) isolates, all extensively drug-resistant (XDR) or multidrug-resistant, carbapenem-resistant K. pneumoniae (CRKp), KPC producers, and previously categorized as susceptible (not resistant) to CZA. No heteroresistance was detected. CZA tolerance/persistence occurred due to ceftazidime tolerance/persistence and was not related to AVI in the CZA combination. 5/11 isolates were characterized as CZA-tolerant and 5/11 as CZA-persistent. The single (1/11) XDR and CRKp non-KPC producer was truly susceptible. All the CZA-tolerant/persistent isolates (ST11, ST258, ST340, ST437, ST16, ST17, and ST307) harbored the carbapenemase-encoding gene blaKPC−2. Mutation in only two genes (rpoS and degQ) related to beta-lactam tolerance/persistence was found in only 7/49 CZA-tolerant/persistent isolates, suggesting the presence of yet unknown beta-lactam tolerance/persistence genes. Conclusion Among the K. pneumoniae bloodstream isolates studied, 60%, previously categorized as susceptible to CZA, were, actually, tolerant/persistent to this antibiotic, all these KPC producers.
#Research#Medicine#Physiology
Public
Mark Wyner Won’t Comply :vm:

Our hearts may have brains:

“Scientists from the Karolinska Institutet in Sweden and Columbia University in the US have now uncovered a startling level of complexity among the neurons encasing the zebrafish’s heart, challenging existing theories on how the organ’s pulse is maintained in animals like ourselves…humans and zebrafish have surprisingly similar cardiovascular physiology.”

sciencealert.com/your-heart-ha

ScienceAlert · Your Heart Has Its Very Own Brain – And It's Surprisingly ComplicatedLong before we're born, our heart's tissues twitch and convulse in a rhythm that only ceases in our final hour.
#Science#Biology#Physiology
Public
SPQR

That doesn't mean that SARS-CoV-2 infection is benign, is inconsequential. We still see people in the hospital with SARS-CoV-2 infection, we still see people with strokes and heart attacks and, you know, brain fog and all other manifestations.
#COVID19 #pathogen #pathology #virology #physiology #BrainScience #neurology #neurobiology #biology #microbiology #health
cbc.ca/radio/quirks/long-covid

CBCCOVID infections are causing drops in IQ and years of brain aging, studies suggest | CBC RadioResearchers are trying to understand the profound effects of COVID-19 on the brain, looking at how it disrupts the blood-brain barrier, how it affects brain volume, and showing that even a mild case of COVID can lead to the equivalent of seven years of brain aging.
Public
JuneSim63

Interesting new study on physiological links to social isolation:

"We investigated the association between proteins and self-reported loneliness and social isolation. We discovered that the proteins found to be significantly associated with loneliness and social isolation are also known to be implicated in inflammation as well as antiviral and immune responses"

#Loneliness #SocialIsolation #Proteins #Physiology #Immunology #Science

theconversation.com/loneliness

The ConversationLoneliness and social isolation are linked to specific proteins – new research
More from The Conversation UK
Public
SPQR

We conclude that healthy older adults show evidence of mitochondrial impairment and muscle weakness, but that this can be partially reversed at the phenotypic level, and substantially reversed at the transcriptome level, following six months of resistance exercise training.
#science #aging #exercise #physiology #biology #pathology #muscles #training #health
journals.plos.org/plosone/arti

journals.plos.orgResistance Exercise Reverses Aging in Human Skeletal MuscleHuman aging is associated with skeletal muscle atrophy and functional impairment (sarcopenia). Multiple lines of evidence suggest that mitochondrial dysfunction is a major contributor to sarcopenia. We evaluated whether healthy aging was associated with a transcriptional profile reflecting mitochondrial impairment and whether resistance exercise could reverse this signature to that approximating a younger physiological age. Skeletal muscle biopsies from healthy older (N = 25) and younger (N = 26) adult men and women were compared using gene expression profiling, and a subset of these were related to measurements of muscle strength. 14 of the older adults had muscle samples taken before and after a six-month resistance exercise-training program. Before exercise training, older adults were 59% weaker than younger, but after six months of training in older adults, strength improved significantly (P<0.001) such that they were only 38% lower than young adults. As a consequence of age, we found 596 genes differentially expressed using a false discovery rate cut-off of 5%. Prior to the exercise training, the transcriptome profile showed a dramatic enrichment of genes associated with mitochondrial function with age. However, following exercise training the transcriptional signature of aging was markedly reversed back to that of younger levels for most genes that were affected by both age and exercise. We conclude that healthy older adults show evidence of mitochondrial impairment and muscle weakness, but that this can be partially reversed at the phenotypic level, and substantially reversed at the transcriptome level, following six months of resistance exercise training.
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Dave Muth

What's does it feel like to be a robot bat?

Sweet! I wonder how life-miming this IS. What shape bat parts play the part of the triangular track in the robot? I'll put on my web-spelunking boots and climb down this rabbit hole... mastodon.social/@thebatbotlab/

(Whew! I haven't found any sci-papers comparing bat physiology and bat-robot "physiology". There are TONS of hits on a search for "adam carmody"--on Threads, Instagram, etc.)

I'm gonna need some bigger boots!
#Physiology #Bats #Maths #Flight

MastodonThe Bat Bot Lab (@thebatbotlab@mastodon.social)Attached: 1 image Design of a coupled flapping & folding mechanism for a biomimetic flapping-flight bat robot. Video: Adam Carmody.
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Sophia Bullock

#Introduction
So here I am, someone who tried and failed Twitter numerous times, now attempting to get a handle on this 😂 I don't know if I'm on the right server, I guess time will tell!

I'm a #PhDStudent at #NewcastleUniversity using #animalBehaviour, #neuroscience, #physiology and #socialScience to improve #laboratory #animalWelfare (jeez that's a lotta hashtags!). 🐀

In my spare time I enjoy hunting, identifying, and sometimes even eating #fungi. I also like #photography and #baking vegan goodies 🍰

Image of a rock formation on a rocky beach with the sea and cliffs in the background. The sky is blue with some white fluffy clouds.
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