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#neuroscience

26 posts22 participants0 posts today
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Science Updates

"What's really important here is that patients themselves were reporting that their lives were improving," said Charles R. Conway, MD, a professor of #psychiatry at Washington University School of Medicine in St. Louis. "You have a population of people that has been failed by a ridiculously high number of treatments, including very aggressive treatments such as electroconvulsive therapy."

#depression #research #science #neuroscience #medicine

labroots.com/trending/clinical

LabrootsTrials Indicate Vagus Nerve Stimulation may Relieve Depression | Clinical And Molecular DxIn clinical trials, almost 500 depression patients who were resistant to current treatments were given therapy that stimulated their vagus nerve. The major | Clinical And Molecular Dx
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Giulio Gabrieli

🔥 I did a thing! 🔥

Here is my new preprint on a non-invasive, high-resolution method to map spinal cord activity! 🧠⚡🦴

What you can find:

📍Cool figures!
📍 attention modulation of spinal activity (yes, spinal!)
📍 Cool videos in the suppmat

🚀 Read it here: biorxiv.org/content/10.1101/20

bioRxiv · Electrical Spinal Imaging (ESI): Analysing spinal cord activity with non-invasive, high-resolution mappingThe spinal cord is the key bridge between the brain and the body. However, scientific understanding of healthy spinal cord function has historically been limited because noninvasive measures of its neural activity have proven exceptionally challenging. In this work, we describe a novel recording and analysis approach to obtain non-invasive, high-resolution images of the electrical activity of the spinal cord in humans (Electrical Spinal Imaging, ESI). ESI is analytically simple, easy to implement, and data-driven: it does not involve template-based strategies prone to produce spurious signals. Using this approach we provide a detailed description and physiological characterization of the spatiotemporal dynamics of the peripheral, spinal and cortical activity elicited by somatosensory stimulation. We also demonstrate that attention modulates post-synaptic activity at spinal cord level.  Our method has enabled four new insights regarding spinal cord activity. (1) We identified three distinct responses in the time domain: sP9, sN13 and sP22. (2) The sP9 is a traveling wave reflecting the afferent volley entering the spinal cord through the dorsal root. (3) In contrast, the sN13 and sP22 reflect segmental post-synaptic activity. (4) While the sP9 response is first seen on the dorsal electrodes ipsilateral to the stimulated side, the sN13 and sP22 were not lateralised with respect to the side of stimulation. (5) Unimodal attention strongly modulates the amplitude of the sP22, but not that of the sP9 and sN13 components. The proposed method offers critical insights into the spatiotemporal dynamics of somatosensory processing within the spinal cord, paving the way for precise non-invasive functional monitoring of the spinal cord  in basic and clinical neurophysiology. ### Competing Interest Statement The authors have declared no competing interest.
#Neuroscience#SpinalCord#EEG
Public
Matt

Excited to receive a new GazePoint GP3 eyetracker today for our testing lab!

This eyetracker is made in Canada, so if you're a researcher looking for one, consider supporting Canadian tech by checking out GazePoint or SR Research

Picture of an bow-tie shaped eyetracker camera system on a tripod resting atop of a yellow notepad on a cluttered computer desk.
#eyetracking#psychology#neuroscience
Public
Albert Cardona

A review: "C. elegans wired and wireless connectome: insights into principles of nervous system structure and function", by K Venkatesh, L Ripoll-Sánchez, I Beets, WR Schafer 2025
link.springer.com/article/10.1

SpringerLinkC. elegans wired and wireless connectome: insights into principles of nervous system structure and function - Journal of BiosciencesCaenorhabditis elegans is one of the primary model organisms for neuroscience research due to its well-annotated and compact nervous system. Being the first organism with a mapped connectome, published nearly 40 years ago, it holds a critical place in the field of neuroscience. Over the past decades, exhaustive mapping of the C. elegans nervous system at the molecular and cellular level, along with the development of tools to probe neural dynamics, have given invaluable insights on neuronal communication at the cellular, circuit, and systems level. In this review, we discuss key features of the C. elegans connectome, the wired (synaptic) as well as the wireless (extrasynaptic) network, and their role in executing complex behaviours. We delve into recent advances in C. elegans neuroscience, highlighting how in vivo and in silico studies have elucidated functional principles that govern sensory integration and the importance of assessing behavioural features at a systems level. With emerging connectomes of other, more complex organisms, this field offers a robust framework for testable hypotheses and comparative connectomics.
#Celegans#connectomics#neuroscience
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