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#neuroscience

28 posts20 participants1 post today
Public
El Duvelle

I'm trying to read a #Neuroscience paper published by #Wiley and it's showing me a banner that says only "healthcare professionals" should be reading the paper. What's up with that? Researchers are not allowed to read papers anymore? 🤔

Impossible to find a way to contact Wiley about it, but maybe someone out there will know them and might be able to ask what is happening?

The paper: Locomotor action sequences impact the scale of
representation in hippocampus and posterior parietal cortex #NitzLab #WileyOnlineLibrary #Academia

Screenshot of a banner seen on the Wiley publisher website when accessing a neuroscience article saying: "This material is only for use by healthcare professionals. By continuing to view this site you are confirming that you are a healthcare professional."
Public
Albert Cardona

Even worms can minimize effort when they have the choice – here, assessed when feeding:

"C. elegans food choice exhibits effort discounting-like behavior", Millet et al. 2025 (Shawn Lockery's lab)

biorxiv.org/content/10.1101/20

bioRxiv · C. elegans food choice exhibits effort discounting-like behaviorCost-benefit decisions are ubiquitous in both human and animal behavior. Economists have developed formal models of cost-benefit decision-making by focusing on discounting behavior, the devaluation of a reward based on the costs associated with it. The phylogenetic limits of discounting behavior remain unknown. Here, we provide evidence that the nematode C. elegans exhibits behavior closely resembling effort discounting. Given a choice between food options that are easy or difficult to consume, worms devalue the latter in a manner predicted by economic models. We identified a plausible mechanism for this behavior based on differential rates of leaving food patches and demonstrated that this mechanism is disrupted by deficits in dopamine signaling, as in rodents. Together, these results establish C. elegans as a potential invertebrate model for discounting behavior and set new phylogenetic bounds on this type of cost-benefit decision-making. ### Competing Interest Statement The authors have declared no competing interest.
#neuroscience#Celegans
Public
Earl K. Miller

And we need to embrace the likely possibility that brains are more than connectivity patterns and their weightings. That is the start, not the end.
Accepting “the bitter lesson” and embracing the brain’s complexity
thetransmitter.org/neuroai/acc
#neuroscience

Data streams into a transparent box.
The Transmitter: Neuroscience News and Perspectives · Accepting “the bitter lesson” and embracing the brain’s complexityBy Eva Dyer
Public
Albert Cardona

Quite the big deal:

"Light-field deep learning enables high-throughput, scattering-mitigated calcium imaging", by Howe et al. 2025 (Amanda Foust lab).
biorxiv.org/content/10.1101/20

Transfers one-photon light field images of Ca2+ sensors monitoring neuronal activity, which suffer from scattering in the mouse brain, to two-photon volumes that don't, using machine learning.

Image volumes acquired at 100 Hz demonstrate 10Hz spike rates.

The dual-mode LFM combines a 2P laser-scanning path with a one-photon LFM. A removable dichroic mirror diverts fluorescence to the photomuliplier tube (PMT) for 2P collection. When the 2P dichroic is disengaged, fluorescence is imaged by the LFM with a microlens array (MLA). Distances not to scale.
#neuroscience#mouse#CalciumImaging
Public
Science Updates

“This is a paradigm-shifting finding,” said first study author George Hoeferlin, Ph.D. “For decades, the field has focused on the body’s immune response to these implants, but our research now shows that bacteria, some originating from the gut, are also playing a role in the inflammation surrounding these devices.”

#brain #health #bacteria #microbiology #neuroscience #science #research

labroots.com/trending/microbio

LabrootsBrain Implants Trigger a Bacterial Invasion | MicrobiologyBrain implants seem to offer many possibilities for patients with neurological problems. They may be able to help reduce seizures in ... | Microbiology
Continued thread
Public
Albert Cardona

This conundrum may originate in the cell type-centric view of connectivity, rather than considering the actual connectome into the analysis. The authors more or less say as much in the discussion:

"two cell types can have similar physiology and relatively similar connectivity without sharing input cell types. Overall, this analysis suggests that defining connection similarity by cell types may overly discretize the network, obscuring structure-function relationships."

#neuroscience#connectomics#CellTypes
Public
Albert Cardona

"Infrequent strong connections constrain connectomic predictions of neuronal function", Currier and Clandinin
biorxiv.org/content/10.1101/20

Quite the reversal from studies showing that deriving connectomes from correlated neural activity is not accurate because of lacking a unique solution:

"we show that physiology is a stronger predictor of wiring than wiring is of physiology"

bioRxiv · Infrequent strong connections constrain connectomic predictions of neuronal functionHow does circuit wiring constrain neural computation? Recent work has leveraged connectomic datasets to predict the function of cells and circuits in the brains of many species. However, many of these hypotheses have not been compared with physiological measurements, obscuring the limits of connectome-based functional predictions. To explore these limits, we characterized the visual responses of 91 cell types in the fruit fly and quantitatively compared them to connectomic predictions. We show that these predictions are accurate for some response properties, such as orientation tuning, but are surprisingly poor for other properties, such as receptive field size. Importantly, strong synaptic inputs are more functionally homogeneous than expected by chance, and exert an outsized influence on postsynaptic responses, providing a powerful modeling constraint. Finally, we show that physiology is a stronger predictor of wiring than wiring is of physiology, revising our understanding of the structure-function relationship in the brain. ### Competing Interest Statement The authors have declared no competing interest.
#neuroscience#Drosophila#connectomics
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