Duncan<p>Can anybody with a knowledge of immunology/ virology explain why we aren’t mass vaccinating the population against H5N1 now?<br>I know we don’t know the exact strain that will go pandemic yet but I thought with previous mass casualty flu pandemics (eg Spanish Flu) the high mortality was caused by the novel HN combination people didn’t have any previous immunity to? Wouldn’t mass immunization against *any* H5N1 strain make us more able to withstand what’s coming? <br><a href="https://mastodon.online/tags/Science" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Science</span></a> <a href="https://mastodon.online/tags/Immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Immunology</span></a> <a href="https://mastodon.online/tags/Virology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Virology</span></a></p>
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#immunology
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Knowable Magazine<p>“I don’t think anyone appreciated the magnitude by which even mild stress, if it’s chronic, can have such a negative influence on cancer growth.” —cancer immunologist Elizabeth Repasky</p><p>People with cancer may experience a wide range of stressors, both related and unrelated to the disease. A growing body of evidence suggests that these may influence how a tumor grows and spreads.</p><p>🔗 Learn more: <a href="https://knowablemagazine.org/content/article/health-disease/2025/how-stress-affects-cancer" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">knowablemagazine.org/content/a</span><span class="invisible">rticle/health-disease/2025/how-stress-affects-cancer</span></a></p><p><a href="https://mstdn.science/tags/KnowableMagazine" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>KnowableMagazine</span></a> <a href="https://mstdn.science/tags/ScienceMastodon" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ScienceMastodon</span></a> <a href="https://mstdn.science/tags/Immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Immunology</span></a> <a href="https://mstdn.science/tags/CancerResearch" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>CancerResearch</span></a></p>
World news | The Guardian<p>Move over, Med diet – plantains and cassava can be as healthy as tomatoes and olive oil, say researchers <a href="https://www.theguardian.com/global-development/2025/apr/17/mediterranean-diet-african-food-tanzania-heritage-traditional-healthy" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">theguardian.com/global-develop</span><span class="invisible">ment/2025/apr/17/mediterranean-diet-african-food-tanzania-heritage-traditional-healthy</span></a> <a href="https://halo.nu/tags/Globaldevelopment" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Globaldevelopment</span></a> <a href="https://halo.nu/tags/Dietsanddieting" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Dietsanddieting</span></a> <a href="https://halo.nu/tags/Globalhealth" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Globalhealth</span></a> <a href="https://halo.nu/tags/Lifeandstyle" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Lifeandstyle</span></a> <a href="https://halo.nu/tags/Foodscience" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Foodscience</span></a> <a href="https://halo.nu/tags/Immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Immunology</span></a> <a href="https://halo.nu/tags/Worldnews" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Worldnews</span></a> <a href="https://halo.nu/tags/Tanzania" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Tanzania</span></a> <a href="https://halo.nu/tags/Science" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Science</span></a> <a href="https://halo.nu/tags/Africa" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Africa</span></a> <a href="https://halo.nu/tags/Food" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Food</span></a></p>
Science | The Guardian<p>Move over, Med diet – plantains and cassava can be as healthy as tomatoes and olive oil, say researchers <a href="https://www.theguardian.com/global-development/2025/apr/17/mediterranean-diet-african-food-tanzania-heritage-traditional-healthy" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">theguardian.com/global-develop</span><span class="invisible">ment/2025/apr/17/mediterranean-diet-african-food-tanzania-heritage-traditional-healthy</span></a> <a href="https://halo.nu/tags/Globaldevelopment" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Globaldevelopment</span></a> <a href="https://halo.nu/tags/Dietsanddieting" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Dietsanddieting</span></a> <a href="https://halo.nu/tags/Globalhealth" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Globalhealth</span></a> <a href="https://halo.nu/tags/Lifeandstyle" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Lifeandstyle</span></a> <a href="https://halo.nu/tags/Foodscience" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Foodscience</span></a> <a href="https://halo.nu/tags/Immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Immunology</span></a> <a href="https://halo.nu/tags/Worldnews" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Worldnews</span></a> <a href="https://halo.nu/tags/Tanzania" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Tanzania</span></a> <a href="https://halo.nu/tags/Science" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Science</span></a> <a href="https://halo.nu/tags/Africa" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Africa</span></a> <a href="https://halo.nu/tags/Food" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Food</span></a></p>
nf-core<p>Pipeline release! nf-core/hlatyping v2.1.0 - 2.1.0 - Chewbacca!</p><p>Please see the changelog: <a href="https://github.com/nf-core/hlatyping/releases/tag/2.1.0" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">github.com/nf-core/hlatyping/r</span><span class="invisible">eleases/tag/2.1.0</span></a></p><p><a href="https://mstdn.science/tags/dna" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>dna</span></a> <a href="https://mstdn.science/tags/hla" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>hla</span></a> <a href="https://mstdn.science/tags/hlatyping" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>hlatyping</span></a> <a href="https://mstdn.science/tags/immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>immunology</span></a> <a href="https://mstdn.science/tags/optitype" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>optitype</span></a> <a href="https://mstdn.science/tags/personalizedmedicine" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>personalizedmedicine</span></a> <a href="https://mstdn.science/tags/rna" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>rna</span></a> <a href="https://mstdn.science/tags/nfcore" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>nfcore</span></a> <a href="https://mstdn.science/tags/openscience" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>openscience</span></a> <a href="https://mstdn.science/tags/nextflow" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>nextflow</span></a> <a href="https://mstdn.science/tags/bioinformatics" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>bioinformatics</span></a></p>
datum (n=1)<p>that Blood Advances paper aligns with earlier autopsy results, and confirmed</p><blockquote><p>SARS-CoV-2+ megakaryocytes are present in lung and brain autopsy tissues from deceased donors who had COVID-19</p></blockquote><p>But heck! We already knew MKs were long-term impacted. This from 2024 <a href="https://ashpublications.org/bloodadvances/article/8/11/2777/515445/SARS-CoV-2-infection-modifies-the-transcriptome-of" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">ashpublications.org/bloodadvan</span><span class="invisible">ces/article/8/11/2777/515445/SARS-CoV-2-infection-modifies-the-transcriptome-of</span></a> - though in mice gives what I guess should be an obvious outcome, since the immune system isn't open-loop:</p><blockquote><p>Megakaryocytes (MKs), integral to platelet production, predominantly reside in the bone marrow. [...] at peak SARS-CoV-2 viremia, when the disease primarily affected the lungs, MKs were not significantly different from those from healthy mice. Conversely, a significant divergence in the MK transcriptome was observed during systemic inflammation, although SARS-CoV-2 RNA was never detected in the BM, and it was no longer detectable in the lungs. Under these conditions, <strong>the MK transcriptional landscape was enriched in pathways associated with histone modifications, MK differentiation, NETosis, and autoimmunity</strong></p><p><strong>and autoimmunity</strong></p></blockquote><p>The breadcrumbs are everywhere.</p><p>fin/🧵 </p><p><a href="https://zeroes.ca/tags/CovidIsAirborne" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>CovidIsAirborne</span></a> <a href="https://zeroes.ca/tags/SARSCoV2" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>SARSCoV2</span></a> <a href="https://zeroes.ca/tags/Covid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Covid</span></a> <a href="https://zeroes.ca/tags/COVID19" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>COVID19</span></a> <a href="https://zeroes.ca/tags/CovidCompetent" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>CovidCompetent</span></a> <a href="https://zeroes.ca/tags/AirborneAware" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>AirborneAware</span></a> <a href="https://zeroes.ca/tags/immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>immunology</span></a></p>
datum (n=1)<p>That aligns with results from 2022-2023 like <a href="https://ashpublications.org/bloodadvances/article/7/15/4200/494910/Circulating-SARS-CoV-2-megakaryocytes-are" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">ashpublications.org/bloodadvan</span><span class="invisible">ces/article/7/15/4200/494910/Circulating-SARS-CoV-2-megakaryocytes-are</span></a> which found</p><blockquote><p>Using peripheral blood, we show that megakaryocytes are increased in the systemic circulation in COVID-19</p></blockquote><p><em>peripheral</em> blood - circulating!!</p><blockquote><p>SARS-CoV-2–containing megakaryocytes are a strong risk factor for mortality and multiorgan injury</p></blockquote><p>2/🧵 </p><p><a href="https://zeroes.ca/tags/CovidIsAirborne" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>CovidIsAirborne</span></a> <a href="https://zeroes.ca/tags/SARSCoV2" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>SARSCoV2</span></a> <a href="https://zeroes.ca/tags/Covid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Covid</span></a> <a href="https://zeroes.ca/tags/COVID19" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>COVID19</span></a> <a href="https://zeroes.ca/tags/CovidCompetent" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>CovidCompetent</span></a> <a href="https://zeroes.ca/tags/AirborneAware" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>AirborneAware</span></a> <a href="https://zeroes.ca/tags/immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>immunology</span></a></p>
datum (n=1)<p>So. How about this careful result demonstrating <strong>viral replication inside megakaryocyte immune cells</strong>?</p><blockquote><p>transmission electron microscopy pointed to the presence of viral particles inside bone marrow MK. Immunolabeling confirmed the presence of two SARS-CoV-2 proteins, spike and Orf3a, as well as double-stranded RNA suggesting a potential viral replication cycle.</p></blockquote><p>Note this study is from last month, but it's from hospitalized 2020-2021 patient data. It's existence proof, not population statistics.</p><p>That said:</p><blockquote><p>bone marrow MK infection is not a strict determinant of mortality. However, all survivors experienced post-acute sequelae SARS-CoV-2 condition (PASC) diagnosed during post-intensive care follow-up</p></blockquote><p>short 🧵 </p><p><a href="https://zeroes.ca/tags/CovidIsAirborne" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>CovidIsAirborne</span></a> <a href="https://zeroes.ca/tags/SARSCoV2" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>SARSCoV2</span></a> <a href="https://zeroes.ca/tags/COVID" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>COVID</span></a> <a href="https://zeroes.ca/tags/COVID19" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>COVID19</span></a> <a href="https://zeroes.ca/tags/CovidCompetent" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>CovidCompetent</span></a> <a href="https://zeroes.ca/tags/AirborneAware" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>AirborneAware</span></a> <a href="https://zeroes.ca/tags/immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>immunology</span></a></p>
eLife<p>A tale of two caspases</p><p>Macrophages control intracellular pathogens like Salmonella by using two caspase enzymes at different times during infection. <a href="https://fediscience.org/tags/Immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Immunology</span></a> <a href="https://fediscience.org/tags/Microbiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Microbiology</span></a><br><a href="https://elifesciences.org/articles/106581?utm_source=mastodon&utm_medium=social&utm_campaign=organic_insights" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">elifesciences.org/articles/106</span><span class="invisible">581?utm_source=mastodon&utm_medium=social&utm_campaign=organic_insights</span></a></p>
datum (n=1)<p><strong>AMA Update from Dr. Akiko Iwasaki, Sterling Professor of Immunobiology, Yale</strong></p>
<p><a href="https://media.zeroes.ca/cache/media_attachments/files/114/302/684/594/520/873/original/058d9a337fda70b0.mp4" rel="nofollow noopener noreferrer" target="_blank">ad-free</a> or <a href="https://www.youtube.com/watch?v=ilIOh4cZiNI" rel="nofollow noopener noreferrer" target="_blank">original</a></p>
<blockquote><strong>Common manifestations of Long COVID [which] are not very well discussed, and many physicians may not be aware of:</strong></blockquote>
<blockquote><strong>Internal tremor</strong> ... Over one third of Long COVID patients report experiencing internal vibration or tremor sensations that are without visible external signs</blockquote>
<blockquote>Postural orthostatic tachycardia syndrome (<a href="https://en.wikipedia.org/wiki/Postural_orthostatic_tachycardia_syndrome" rel="nofollow noopener noreferrer" target="_blank">POTS</a>)</blockquote>
<blockquote>Post-Exertional Malaise (PEM)</blockquote>
<blockquote>Hormonal dysregulations</blockquote>
<blockquote>Sleep disturbance</blockquote>
<p>If you're a physician <i>are</i> these surprising to you? Are the four identified endotypes surprising?</p>
<p>via <a href="https://zeroes.ca/@trendless/114304265960580458" rel="nofollow noopener noreferrer" target="_blank">https://zeroes.ca/@trendless/114304265960580458</a></p>
<br>
#medstodon #medicine #immunology #LongCOVID #SARSCoV2 #PASC
Katie Fleeman<p>“I don’t think anyone appreciated the magnitude by which even mild stress, if it’s chronic, can have such a negative influence on cancer growth.”</p><p>Studies show psychological strain can accelerate tumors — could beta blockers slow them down?</p><p>👉 Read more: <a href="https://knowablemagazine.org/content/article/health-disease/2025/how-stress-affects-cancer" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">knowablemagazine.org/content/a</span><span class="invisible">rticle/health-disease/2025/how-stress-affects-cancer</span></a> </p><p>📝 Diana Kwon for <span class="h-card" translate="no"><a href="https://mstdn.science/@KnowableMag" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@<span>KnowableMag</span></a></span> </p><p><a href="https://mastodon.social/tags/KnowableMagazine" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>KnowableMagazine</span></a> <a href="https://mastodon.social/tags/ScienceMastodon" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ScienceMastodon</span></a> <a href="https://mastodon.social/tags/Immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Immunology</span></a></p>
Science Updates<p>How is the neurotransmitter acetylcholine inveolved in IBD? Researchers have just revealed more about gut physiology that may help improve treatments for IBD, and which don't try to suppress immunity...</p><p><a href="https://mastodon.social/tags/immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>immunology</span></a> <a href="https://mastodon.social/tags/IBD" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>IBD</span></a> <a href="https://mastodon.social/tags/gut" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>gut</span></a> <a href="https://mastodon.social/tags/health" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>health</span></a> <a href="https://mastodon.social/tags/medicine" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>medicine</span></a> <a href="https://mastodon.social/tags/research" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>research</span></a> <a href="https://mastodon.social/tags/science" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>science</span></a> <a href="https://mastodon.social/tags/biology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>biology</span></a> </p><p><a href="https://www.labroots.com/trending/genetics-and-genomics/28753/gut-pressure-sensor-reduce-inflammation" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">labroots.com/trending/genetics</span><span class="invisible">-and-genomics/28753/gut-pressure-sensor-reduce-inflammation</span></a></p>
Science Updates<p>"...if you can figure out how a rare disease mutation is working, you learn something about the normal proteins that all of us have," noted Dr Jonathan Miner, MD, PhD.</p><p>Insights into a rare disease known as SAVI have put a spotlight on a major immune trigger.</p><p><a href="https://mastodon.social/tags/immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>immunology</span></a> <a href="https://mastodon.social/tags/autoimmunity" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>autoimmunity</span></a> <a href="https://mastodon.social/tags/disease" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>disease</span></a> <a href="https://mastodon.social/tags/health" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>health</span></a> <a href="https://mastodon.social/tags/medicine" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>medicine</span></a> <a href="https://mastodon.social/tags/research" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>research</span></a> <a href="https://mastodon.social/tags/science" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>science</span></a> <br> </p><p><a href="https://www.labroots.com/trending/cell-and-molecular-biology/28740/key-trigger-immune-overactivity-identified" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">labroots.com/trending/cell-and</span><span class="invisible">-molecular-biology/28740/key-trigger-immune-overactivity-identified</span></a></p>
David Usharauli<p>6/ 🔬 These inconsistencies raise key questions about how Treg suppression works in different contexts. More research needed! 🏗️📖</p><p>What do you think? Drop your thoughts below! ⬇️💬 </p><p><a href="https://bookstodon.com/tags/immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>immunology</span></a><br><a href="https://bookstodon.com/tags/Tregs" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Tregs</span></a><br><a href="https://bookstodon.com/tags/Foxp3" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Foxp3</span></a><br><a href="https://bookstodon.com/tags/science" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>science</span></a></p>
David Usharauli<p>1/ 📢 A new study was recently published in Science Translational Medicine investigating antigen specificity in Treg-mediated suppression of effector T cells in a celiac model. 🔬🍞 </p><p><a href="https://bookstodon.com/tags/Foxp3" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Foxp3</span></a><br><a href="https://bookstodon.com/tags/Tregs" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Tregs</span></a><br><a href="https://bookstodon.com/tags/celiac" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>celiac</span></a><br><a href="https://bookstodon.com/tags/immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>immunology</span></a><br><a href="https://bookstodon.com/tags/science" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>science</span></a></p><p><a href="https://www.science.org/doi/10.1126/scitranslmed.adr8941" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">science.org/doi/10.1126/scitra</span><span class="invisible">nslmed.adr8941</span></a></p>
David Usharauli<p>8/ Could there be a self-antigen that keeps Tregs and IL-2+ T cells together while autoimmunity targets other self-antigens? Unlikely, as Treg inhibition is antigen-specific. <br>🛑 <br><a href="https://bookstodon.com/tags/Immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Immunology</span></a></p>
David Usharauli<p>1/ 🧵 What is the TCR specificity of Foxp3+ Tregs? They're as diverse as conventional T cells, but very few antigen-specific Tregs have been described. This lack of specificity leads to many unfounded statements. Let's dive in. 🔬 </p><p><a href="https://bookstodon.com/tags/science" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>science</span></a><br><a href="https://bookstodon.com/tags/Immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Immunology</span></a> <br><a href="https://bookstodon.com/tags/Foxp3" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Foxp3</span></a><br><a href="https://bookstodon.com/tags/Tregs" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Tregs</span></a></p>
RDN<p>Screening of blood samples from 157 people born between 1927 and 2016 found that those born before 1968 had higher levels of antibodies for the bird flu (H5N1) virus, likely as a result of exposure to H1N1 or N2N2 viruses as children.</p><p>Summary: <a href="https://www.pennmedicine.org/news/news-releases/2025/march/older-adults-may-be-more-resistant-to-bird-flu" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">pennmedicine.org/news/news-rel</span><span class="invisible">eases/2025/march/older-adults-may-be-more-resistant-to-bird-flu</span></a></p><p>Original paper (not open access): <a href="https://www.nature.com/articles/s41591-025-03599-6" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">nature.com/articles/s41591-025</span><span class="invisible">-03599-6</span></a></p><p><a href="https://floss.social/tags/Science" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Science</span></a> <a href="https://floss.social/tags/Health" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Health</span></a> <a href="https://floss.social/tags/Immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Immunology</span></a> <a href="https://floss.social/tags/BirdFlu" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>BirdFlu</span></a> <a href="https://floss.social/tags/H5N1" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>H5N1</span></a></p>
Garry Knight<p>Scientists discover new part of the immune system</p><p>'A new part of the immune system has been discovered and it is a goldmine of potential antibiotics, scientists have said'</p><p><a href="https://mstdn.social/tags/science" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>science</span></a> <a href="https://mstdn.social/tags/medicine" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>medicine</span></a> <a href="https://mstdn.social/tags/health" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>health</span></a> <a href="https://mstdn.social/tags/immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>immunology</span></a> </p><p><a href="https://www.bbc.co.uk/news/articles/cpv4jww3r4eo" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">bbc.co.uk/news/articles/cpv4jw</span><span class="invisible">w3r4eo</span></a></p>
datum (n=1)AJ's got a new blog post! Some highlights:
<blockquote>"a Nature Immunology study from January 2024 "Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2" reveals further harm through T cell dysregulation in long COVID patients. The research identified increased frequencies of exhausted SARS-CoV-2-specific CD8+ T cells, alongside CD4+ T cells primed for inflammation, and a lack of coordination between T and B cell responses."</blockquote>
<blockquote>"a paper in JCI insight showing T cell exhaustion to other infections following a covid infection"</blockquote>
<blockquote>"a Nature Immunology study from January 2022 "Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection" shows that COVID-19 leads to a prolonged reduction in naive T cells (both CD4+ and CD8+) in individuals with long COVID, persisting up to eight months post-infection."</blockquote>
<blockquote>"Such a long-term impact on the naive T cell pool is not a standard feature of recovery from other acute viral infections like influenza, [...] This effect may not completely persist, however, what it represents is sloughing of the T cells."</blockquote>
<blockquote>A study published in Immunity found "Even after vaccination, those with a history of COVID-19 showed weaker and less functional CD8+ T cell responses, a phenomenon likened to the immune damage seen in chronic viral infections like hepatitis C or HIV. This attenuation indicates that SARS-CoV-2 inflicts a lasting impairment on CD8+ T cell effector function"</blockquote>
from <a href="https://www.easychair.info/p/5-years-later-covid-still-harms-t" rel="nofollow noopener noreferrer" target="_blank">https://www.easychair.info/p/5-years-later-covid-still-harms-t</a>
#AirborneAware #CovidCompetent #COVIDIsNotOver #COVID #COVID19 #SARSCoV2 #immunology #LongCOVID
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