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#philadelphia

49 posts34 participants4 posts today
Public
Holly

#stem #science #health #medicine #alzheimers #cells #research #spiffy #Philadelphia #Pennsylvania

Discovery of mitochondrial protein opens a path to therapeutic advances for heart and Alzheimer's disease if we ever get our support of actual, factual science back

eurekalert.org/news-releases/1

EurekAlert!Discovery of mitochondrial protein by researchers at Lewis Katz School of Medicine at Temple University opens path to therapeutic advances for heart and Alzheimer’s disease(Philadelphia, PA) – Calcium transport into and out of mitochondria – the powerhouses of cells – is central to cellular energy production and cell death. To maintain the balance of calcium within these powerhouses, cells rely on a protein known as the mitochondrial sodium-calcium exchanger, or NCLX. Now, in new research, scientists at the Lewis Katz School of Medicine at Temple University have discovered a novel regulator of NCLX activity, a protein called TMEM65, which helps move calcium out of mitochondria, protecting against harmful calcium overload. The discovery, described online April 8 in the journal Nature Metabolism, is the first to characterize the interaction of TMEM65 with NCLX in mitochondria. “TMEM65 is the first protein identified that is a bona fide interactor and regulator of NCLX,” explained John W. Elrod, PhD, W.W. Smith Chair in Cardiovascular Medicine and Founding Director of the Aging + Cardiovascular Discovery Center at the Lewis Katz School of Medicine and senior investigator on the new study. The discovery could help scientists design new therapeutic agents to combat calcium overload of mitochondria in conditions such as heart failure and Alzheimer’s disease.
Public
Miss Fidget

Be wary of the free dirt from the City of Philadelphia. Use it for backfill not gardening.

Used it few yrs back and lost over half my garden and still fighting to save a big tree. Emailed the county agent for advice. They said the free dirt often contains Roundup which caused my issues. Srsly. Caveat emptor.

phila.gov/services/trees-parks

City of PhiladelphiaGet organic materials | ServicesHow to get free or low-cost compost, mulch, and wood chips at the Fairmount Park Organic Recycling Center.
#Philly#Gardening#Philadelphia
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jesse jarnow

40 years ago today, the #GratefulDead open 3 nights at the #philadelphia spectrum to close their east coast tour. fun in places, but a candidate for the worst-sounding garcia vocals (non-january ’78 division). a cheery pre-tour garcia interview, though. spring ’85, show #16.
soundboard: archive.org/details/gd1985-04-
stephen thomas audience tape: archive.org/details/gd1985-04- [1/5]

newspaper ad electric factory presents Annual Spring Party! Live in Concert Grateful Dead Dance Concert Sat, Sun., Mon April 6, 7, 7 7pm Reserved & Gen Adm $13.50
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